Been working through what works emulation wise on Windows 10. So far Snes and Nes stuff has caused no problems as both FCEUX and Higan work perfectly.
Both Yabause and SSF are working perfectly for Sega Saturn stuff and if I cared about Megadrive or lower then I suspect that it would work as well.
I finally managed to get both Playstation 2 and Gamecube and Wii emulation working at full speed so PCSX2 and Dolphin are working well. Tested with a disc version of Final Fantasy 12 and Bubble Bobble Plus and as an aside found that Wii games cannot be played directly from disc unless you have a specific drive to play them on (thanks a bunch Nintendo).
Hand held wise BGB works for Gameboy and WScamp for Wonderswan does OK as well.
I haven't tested either arcade or old computer things yet although I do have copies of MAME, FBA and Raine on an old drive that I can test out and a Sharp X68OOO emulator that hasn't been updated in years.
In fact the only problems I can find is Playstation emulation. EPSXE crashes "everytiem" and has never gone in game despite multiple plug ins and configurations. PCSX is massively fast when we tested it with Front Mission 3 and eventually ends up with a blast of noise that would make Masami Akita proud. In fact its only PSX which works despite it being abandoned now.